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Category Archive: Controversies

Antidepressants in Bipolar II: What the Experts Do

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We update the research on antidepressants in bipolar disorder, and 18 experts weigh in on how they use these medications in bipolar II disorder in this podcast.

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Do Benzos Treat Depression?

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Around 50 controlled trials have tested benzodiazepines in depression, and the results are surprising. In this episode we look at the controversies surrounding this research and what it means for practice.

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When Depression Gets Worse on an Antidepressant

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When depression gets worse on an antidepressant, it doesn’t necessarily mean the patient has bipolar disorder or that […]

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Ritalin, Provigil, and Caffeine Compared

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How do methylphenidate (Ritalin), modafinil (Provigil), and caffeine affect memory and attention? A new study compares them in healthy men.

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Antidepressants in Bipolar Disorder: The Controversies

There are at least 9 alternatives with at least as much evidence as antidepressants for effectiveness in bipolar […]

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Antidepressant Controversy 2: Do They Cause Mania/Hypomania?

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(updated 11/2014; continued from the main Antidepressant Controversies page) The bottom line: Switching into mania and hypomania happens on […]

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Antidepressant Controversy 5: Continue or Taper?

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Should you continue antidepressants or stop them in bipolar disorder? Here’s the research.

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Antidepressant Controversy 4: Tolerance and Kindling: Can Antidepressants Stop Working?

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Can antidepressants stop working in bipolar disorder? Can they cause tolerance?Here’s the evidence.

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Antidepressant controversy 3: Antidepressants as Mood Destabilizers?

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Do antidepressants destabilize mood in bipolar disorder? It looks like they can, and here’s the evidence.

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Antidepressant Controversy 2: Do They Cause Mania?

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Antidepressants can cause mania, but how often they do depends on the study.

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Antidepressant Controversy 1: Do they Even Work in Bipolar Disorder?

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Antidepressants usually don’t work in bipolar disorder, but a few people respond well to them. It’s just hard to know who they are.

ControversiesMeds ControversiesMeds

Marijuana and Bipolar Disorder

More than a few patients have heard me admit: “well, your drug is better than my drugs.” We’ve […]

Controversies Controversies

Antidepressant Withdrawal Can Last Months?

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Summary When a patient with bipolar disorder is taking an antidepressant, and the decision is made to stop […]

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Antidepressants and Suicidal Thinking: A Biologic Marker?

Revised 11/2014 The United States Food and Drug Administration (FDA) raised a huge controversy when it required a […]

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Psychiatric Times Point/Counterpoint

Altshuler and Ghaemi Psychiatric Times no longer offers the original, actual essays. For historical purposes these seemed worth saving. […]

Controversies Controversies

Chapter 5: The Big Picture

Is there Some Evolutionary Advantage to Bipolar? Evolution did not select out bipolar disorder because the genes which […]

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Is there something wrong with TrueHope?

(Here’s a summary on the use of this agent in bipolar disorder). Update 2014: there was a lot […]

ControversiesNatural Therapies ControversiesNatural Therapies

Lithium Orotate

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Summary Lithium orotate might be a good idea, especially for some people. It may have some risks too. […]

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