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Category Archive: Controversies

Ritalin, Provigil, and Caffeine Compared

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How do methylphenidate (Ritalin), modafinil (Provigil), and caffeine affect memory and attention? A new study compares them in healthy men.

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Antidepressants in Bipolar Disorder: The Controversies

There are at least 9 alternatives with at least as much evidence as antidepressants for effectiveness in bipolar […]

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Antidepressant Controversy 2: Do They Cause Mania/Hypomania?

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The bottom line: Switching happens, but how often seems to vary widely, depending on the study you look […]

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Antidepressant Controversy 5: Continue or Taper?

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Should you continue antidepressants or stop them in bipolar disorder? Here’s the research.

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Antidepressant Controversy 4: Tolerance and Kindling: Can Antidepressants Stop Working?

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Can antidepressants stop working in bipolar disorder? Can they cause tolerance?Here’s the evidence.

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Antidepressant controversy 3: Antidepressants as Mood Destabilizers?

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Do antidepressants destabilize mood in bipolar disorder? It looks like they can, and here’s the evidence.

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Antidepressant Controversy 2: Do They Cause Mania?

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Antidepressants can cause mania, but how often they do depends on the study.

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Antidepressant Controversy 1: Do they Even Work in Bipolar Disorder?

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Antidepressants usually don’t work in bipolar disorder, but a few people respond well to them. It’s just hard to know who they are.

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Marijuana and Bipolar Disorder

More than a few patients have heard me admit: “well, your drug is better than my drugs.” We’ve […]

Controversies Controversies

Antidepressant Withdrawal Can Last Months?

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Summary When a patient with bipolar disorder is taking an antidepressant, and the decision is made to stop […]

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Antidepressants and Suicidal Thinking: A Biologic Marker?

Revised 11/2014 The United States Food and Drug Administration (FDA) raised a huge controversy when it required a […]

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Psychiatric Times Point/Counterpoint

Altshuler and Ghaemi Psychiatric Times no longer offers the original, actual essays. For historical purposes these seemed worth saving. […]

Controversies Controversies

Chapter 5: The Big Picture

Is there Some Evolutionary Advantage to Bipolar? Evolution did not select out bipolar disorder because the genes which […]

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Is there something wrong with TrueHope?

(Here’s a summary on the use of this agent in bipolar disorder). Update 2014: there was a lot […]

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Lithium Orotate

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Summary Lithium orotate might be a good idea, especially for some people. It may have some risks too. […]

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The NIMH’s RDoC and the DSM-5

Two weeks before the DSM- 5 came out, the head of the National Institute of Mental Health (NIMH) […]

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Bipolar or Borderline: disagreement

A reader forwarded the graph and the table below, inviting their inclusion. Although these are the work of […]

ControversiesMood Spectrum ControversiesMood Spectrum

Bipolar Disorder and Borderline Personality Disorder: What’s the Difference?

First, My Plain-er English Conclusion If you’re not a psychiatrist interested in this subject, this page is likely […]

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