A guide to depression, bipolar, and brain health from Jim Phelps, MD and Chris Aiken, MD. Start with our new video below.

Recent Posts

  • Can A Sleep Med Make Antidepressants Work Better?
    When you sleep better you feel better, so it shouldn’t come as a surprise that a sleep medicine […]
  • Antidepressants in Bipolar II: What the Experts Do
    We update the research on antidepressants in bipolar disorder, and 18 experts weigh in on how they use these medications in bipolar II disorder in this podcast.
  • Mood, Metabolism, and Cognition: An Interview with Rodrigo Mansur
    In this podcast we look at three ways that the body influences the brain – through neurohormones, inflammation, and metabolic health. Dr. Rodrigo Mansur delves into that last one in our expert interview, and we end with a new app – Thinc-IT – that measures cognition in patients.
  • Do Benzos Treat Depression?
    Around 50 controlled trials have tested benzodiazepines in depression, and the results are surprising. In this episode we look at the controversies surrounding this research and what it means for practice.
  • COVID, Benzos, and Opioids
    Overdose deaths have been rising during COVID, but simply stopping the drug causes problems of its own. In this podcast, Ashwin Patkar and Richard Weisler discuss how to reduce the risk of opioid deaths in psychiatric patients.
  • How to Stop Benzos and Stimulants
    Swapnil Gupta, author of Deprescribing in Psychiatry, shares tips on how to help patients taper off benzodiazepines and psychostimulants in this podcast. She adds a special therapeutic ingredient, but it’s not a medication. Then we digress into one of the oldest medications known to humankind: Opium.
  • Hagop Akiskal and the Bipolar Spectrum
    Hagop Akiskal was known for the bipolar spectrum, but that was just the latest in a 50 year career that constantly pushed psychiatry in new directions. As soon as his ideas entered the mainstream, he moved on to the next controversy, and on January 20th 2021 he moved on from this life. In this podcast, we look back on his legacy, beginning in the early 1970’s when Dr. Akiskal reshaped the way we think about depression, particularly the false dichotomy between stress-induced vs. biological depression.

Online Books

The Mood Spectrum

1 in 3 people with depression fall in the middle of the mood spectrum (aka bipolar spectrum). Learn what that means and how to treat it.

Antidepressants in Bipolar

Learn whether they work, when they make things worse, and how to come off them

Genes, Stress, and the Brain

How genes interact with stress to shape the brain

The Bipolar Brain

Mechanisms and causes of bipolar and depression

Paper Books

Depression and Bipolar Workbook

30 lifestyle changes you can make that treat depression and stabilize bipolar.

A Spectrum Approach to Mood Disorders

A practical textbook for physicians, nurses, therapists, and those who want to understand the science behind the spectrum.

Bipolar, Not So Much

How the mood spectrum looks in real life, with detailed chapters on natural therapies, medications, and tips for friends and family.


  1. Diagnosis in the Mood Spectrum
  2. Depression is not a Moral Weakness
  3. Mixed States, Depression & Anxiety
  4. Treatment Basics: The Middle of the Mood Spectrum
  5. Antidepressants that aren’t “Antidepressants”
  6. How to Choose a Mood Stabilizer
  7. Dark Therapy for Sleep and Bipolar