Hagop Akiskal was known for the bipolar spectrum, but that was just the latest in a 50 year career that constantly pushed psychiatry in new directions. As soon as his ideas entered the mainstream, he moved on to the next controversy, and on January 20th 2021 he moved on from this life. In this podcast, we look back on his legacy, beginning in the early 1970’s when Dr. Akiskal reshaped the way we think about depression, particularly the false dichotomy between stress-induced vs. biological depression.