What's the difference between bipolar disorder and "Borderline
(partial update 9/2009; addition 5/2013)
Author's Note 9/2005: If you're not a psychiatrist interested in this subject, this page is likely to be harder to read than most of the rest of this website. My apologies. This essay began several years ago as a presentation of my view on this subject, to save me time in explaining it. I was working on the inpatient unit of our hospital at the time, and this subject comes up every day there. However, since that time I've used this page as a place to keep track of interesting references on the subject. The result is that there are too many article links to read very smoothly anymore. If you just skim along, at first, you may see my main point: trying to distinguish these two conditions is difficult because they share so many characteristics; and besides, the treatments to be considered are so similar, in the end it may be easier to give up trying to distinguish them. They may not be entirely separate conditions anyway, but even if they were, if for now the treatments are basically the same, why struggle so much with the naming?
In the material below, you'll see the focus is on "how are they treated?" because presumably that is what diagnosis is supposed to be guiding. Although generally very similar, there are two important differences in treatment. In bipolar disorder, one uses antidepressants only with caution, whereas they are routinely used in the treatment of "borderline personality disorder." Secondly, borderline treatment relies primarily on psychotherapy with medications coming second. Bipolar disorder is pretty clearly handled the other way around, with bipolar-specific psychotherapies coming second to medications (in general, no one advocates treating an average patient with bipolar disorder with psychotherapy alone).
Yet the psychotherapy for borderline is not going to make bipolar worse, rather quite the opposite in most cases I think. And the medications for bipolar disorder frequently make borderline better (including, in my experience, not just mood stabilizers, but also avoiding reliance on antidepressants in favor of an emphasis on mood stabilizers, in fact deliberately avoiding antidepressants at least for a time to see if that makes things turn out better). So I arrive at the conclusion that trying to distinguish these conditions creates more trouble than it solves. Have a look.
Research on the Overlap of Bipolar Disorder and Borderline Personality Disorder
[Apologies, 9/2009: I've not updated this page in several years. Many more articles than listed here have since appeared. But in general, my viewpoint has not altered despite a growing sense -- I'll admit -- that there really is a valid distinction between these two conditions. I still think that for now, what really matters is "how are you going to treat this person", and that has not changed much in the last 5 years. Psychotherapy is very important, particularly for "borderline" (I still hate the term, too), where more therapies now have good evidence for their effectiveness.]
You may have heard about or even been told you are "borderline". This used to be a very negative label, but now there's good evidence that specific treatment is possible and can help a lot.Linehan et al, Meares So now the label is not as pessimistic and hopeless as it was even a few years ago. On the other hand, Dr. Akiskal, one of the most outspoken researchers on bipolar disorder, often states that he does not believe "borderline" exists. Those who would like references on this point of view will find them in his rant against the borderline diagnosis from December 2004, online.
A recent review from Canada found substantial overlap between borderline and bipolar disorder diagnoses, though still concluded that borderline deserved to be regarded as a valid diagnosis, separate from bipolar disorder.Magill This is an excellent review of this "overlap or one illness" issue, and I rather agree with the conclusion. Another borderline research group, led by Dr. Gunderson who's been studying this phenomenon for decades, also warns against lumping the two conditions together.Gunderson He emphasizes the same differentiating factor I present in the next section: abandonment fear is prominent in borderline, not so in bipolar.
Although a recent opinion suggested that collapsing borderline into bipolar disorder would help both patients and doctors.Smith et al , a nearly opposite point of view was expressed in the same journal issueParis , with an accompanying editorial overview.Birnbaum To me the most interesting thing about these commentaries is that the authors presumably were examining the very same data, at least when they began the task, and yet derive opposite conclusions. When a very broad concept of bipolarity was used, 80% of patients with a diagnosis of borderline personality were found to have bipolar features.Deltito As a last relevant research study, here's one more: an Italian bipolar disorder specialist examined the specific symptoms found in bipolar disorder and in patients with "borderline traits" on a structured diagnostic interview. He found that mood instability was common to both, whereas impulsivity was more associated with the borderline traitsBenazzi (although impulsivity has been characterized as a central feature of bipolarity by another research team Swann).
Interestingly, when a group of patients with a diagnosis of bipolar disorder was studied for "maladaptive personality traits", a substantial decrease was found when the patients' mood disorder was treated.Peselow Kind of makes you wonder if the same might be true for patients diagnosed as "borderline"?
[Update August 2003: here's a stunning new research finding that in my opinion says a great deal about the nature of "borderline". A team from the National Institutes of Mental Health, including Dr. Bob Post, who has published a lot about bipolar disorder, studied a woman with "borderline personality disorder" for nearly a year in their research hospital. They found that when this woman had depression, and especially when she had psychotic symptoms (e.g. becoming paranoid, hearing voices), she had increased levels of an antibody to thyroid tissue in her bloodstream.Geracioti Huh?
What is the connection here? Well, we know that one type of thyroid disease is associated with these "autoantibodies" -- antibodies directed toward one's own tissues, in this case thyroid tissue. That is called Hashimoto's thyroiditis. There is some connection between thyroid problems and mood problems, that's clear, but the nature of the connection is not understood. So, it's a mystery as to why this woman's thyroid antibodies would vary along with her mood and other symptoms. Is the thyroid change causing the mood change? Or is it the other way around? Or is some third problem causing both at the same time? Just keep watching for more information on how thyroid, which is similarly mysteriously involved in bipolar disorder, affects complex mood conditions.]
The Overlap Between Diagnostic Criteria
There is tremendous overlap in the symptom patterns of bipolar and borderline personality disorder (Borderline PD). The overlap reflects a basic problem with the concept of a "diagnosis" in the first place; for a brief essay on this topic, click here. Notice in the table below that almost every symptom is found in each column:
|Borderline PD (DSM list)||Bipolar (broad view)|
Some doctors believe self-harm is "diagnostic" of borderline PD, or worse yet, synonymous: all borderlines cut, and anybody who cuts is borderline. It's hard, let me tell you, to convince them it isn't that simple. Here's a case history of cutting in a patient who had bipolar disorder. I've seen several myself. Read one of the very helpful websites on self-harm if you need more information on this common behavior.
However, I think there is indeed one symptom that differentiates the two (to the extent there's any point in doing so; more on that in a moment). You noticed the big yellow blank in the table, yes? People with profound fear of abandonment, and a feeling of chronic emptiness, have a different struggle in life from those who don't have these problems. Recently one of the most prominent borderline specialists, Dr. Glen Gabbard, emphasized these symptoms as the core of "borderline" experience.Gabbard
In my practice, I've had patients who do not have chronic emptiness or abandonment fears who do have self-harm behaviors, which show up when they are extremely agitated. These patients all seem to have figured out that cutting or other forms of self-harm (I had one patient who hit herself on the head with a rolling pin) somehow helped them cope with the intensity of the rest of their symptoms. I have no doubt now that self-harm behaviors are an attempt to "treat" the severe agitation somehow; but that behavior seems rather quickly to disappear when the agitation is controlled.
There are good treatments for both conditions. Borderline PD is usually treated with psychotherapy as the main tool, with medications as needed or to the extent that they are helpful. Bipolar disorder is treated just the other way around: start with medications as the core ingredients in treatment, but using psychotherapy wherever it might be helpful.
All of the medications we routinely use in treating bipolar disorder have been shown in published studies to have some value in borderline PDSoloff: antidepressants, mood stabilizers, and antipsychotics. (The mood stabilizers and modern antipsychotics are all presented, each with a page of details on benefits and risks, on my mood stabilizer list page). Here are some of the studies:
At least two studies have been published both showing that "borderline personality disorder" patients respond to DepakoteHollander ,Frankenburg. A pair of recent studies showed response to Zyprexa was greater than to placebo.Bogenshutz,Zanarini A small randomized trial showed lamotrigine was better than placebo in patients with borderline diagnoses.Reich Similarly, a research team looked back at "borderline" symptoms in the pair of large lamotrigine studies for bipolar patients, and found that "borderline" symptoms appeared to improve along with the bipolar symptoms.Preston
Most recently, aripiprazole has also been shown to be better than placebo for patients with borderline personality disorder.Nickel Lithium has not been studied in a controlled trial in borderline personality disorder, but is advocated for "targeting specific symptom domains" such as mood instability; I did not find anything newer about lithium than the old review by Soloff in 1994, which also includes a review of the use of carbamazepine in borderline.
Therefore it seems even safer now than several years ago (when I first wrote this essay) to say that "mood stabilizer" medications typically thought of for bipolar disorder are also worth thinking of in borderline PD.
The best studied technique for borderline personality disorder is "dialectic behavior therapy", designed and studied initially by Dr. Marsha Linehan. Here is a brief and moderately technical overview; and a remarkable site that describes DBT from the user's perspective, with lots of useful details including how to make your own flash cards, and links to Linehan's lectures (some have even been transcribed). This technique is distinguished from the approaches which proceeded it in (at least) three ways:
A group in Europe used the Linehan treatment approach, and got the same results as in Dr. Linehan's original researchLinehan et al, namely a dramatic decrease in suicidal and self-harm behaviors, although they point out that the big improvements came for the patients with the most severe symptoms.Verheul They suggest that the Linehan DBT approach may be best suited for patient with severe self-harm and suicidal behavior, and that other therapies might be more appropriate for patients without these behaviors -- because DBT does not seem to affect mood symptoms very much. Thus, there may be even more reason, supported by the Verheul study, to think about medications for mood, as well as psychotherapies for mood (after DBT for self-harm and suicidality, if present). \=
Update 9/2009: other therapies which have emerged as effective for borderline in randomized clnical trials (RCTd):
Let's Ask Directly: Does Diagnosis Affect Treatment?
Imagine there really is a difference between these two conditions. We don't really know that now. But imagine there is one, some difference in the structure of the limbic system, the emotion system of the brain, perhaps. And imagine that we had some great lab test that could tell the two apart perfectly (that's rarely the case even with an excellent lab test, by the way, so don't hold your breath). Now, suppose you really have "borderline", but you get called "bipolar ". What happens? You get treated primarily with medications. These might help, as those studies I mentioned a moment ago indicate. But you would still need some help with feelings of abandonment and emptiness (and the problems with relationships that come up when you have those feelings). Unless you had a really rigid psychiatrist or mental health system, you could then try to get a psychotherapy to address these.
What about the other way around? Suppose by our magic test you "really" have bipolar, but get diagnosed borderline PD. Well, until recently, this was the big problem. You'd get labeled as "personality disorder" and often your medical care, from primary care as well as mental health providers, would change accordingly. You'd get shunted to the bottom of the list of patients someone might want to take into a practice. You'd be told that your situation was basically unchangeable except with years of psychotherapy, and then discharged from the hospital no matter what your symptoms were, as was one of my patients only several months ago. (Even if you "really" have borderline PD you shouldn't be treated this way anymore: if our mental health system were perfect (right), you would be found in some deliberate screening program to have borderline PD and placed in a treatment program designed for your condition. Hmm, sounds like how they treat diabetes, doesn't it?).
But back to our example: you're "really" bipolar, but you get diagnosed "borderline". Even if you were initially treated with psychotherapy, ideally it would be noticed that you were not improving fully, and might need medication treatment as well. And hopefully, since mood instability is your primary problem (not plain depression, nor psychosis), you would then be treated with mood stabilizers.
The point here is that you would not necessarily be lead into a treatment that can harm you with the "wrong" diagnosis, either way. You might well get a treatment that could be helpful, even if it is not the "core treatment" you will eventually need (and hopefully get). For a further discussion of how "diagnosis" is being re-worked in mental health, and what that means for the distinction between bipolar and borderline, click here.
However, diagnoses also help predict how things are likely to go in the future -- "prognosis". For borderline personality disorder, the prognosis is not as good: responding to a medication so well that symptoms disappear completely, which is frequent in bipolar disorder (at least one person in 4 gets that kind of response; and only about 1 in 5 shows no improvement, with the rest of the group in the middle somewhere). So one of the risks in labeling a person bipolar, who "really" is borderline (as if we knew that there really is a "real" difference at some biological level, which we don't), is that it might raise too much hope of a good outcome.
Worse yet, people with borderline-ness are prone to idealizing their doctors and therapists. So raising hope (for example, by emphasizing "bipolar" and the possibility of a great response) plays right into that idealizing, with increased potential for great disappointment later when treatment does not work as hoped (as emphasized by Gunderson in his 2006 interview). That great disappointment can likewise be magnified by people with borderline-ness, sort of a mirror image of the initial idealization and hopefulness. This overidealization and later strong devaluation are well-recognized phenomena in borderline-ness. Since suicide attempts are also very common in people who meet the DSM diagnostic rules for "borderline personality disorder", you can see the problem here: raising hopes that get dashed later can lead to an intense hopelessness to which the person is already prone, and hopelessness is a well-known risk factor for suicide.
Therefore may I caution: assuming that a person is not "really" borderline, and is instead "really" bipolar, can add risk. We should all watch out for that. At the same time, assuming that a patient is "really" borderline when he/she might have bipolar disorder also clearly adds risk: it lowers the hope that an excellent treatment response is possible, which is a very terrible thing for a doctor to do to a patient and her/his family. It also lowers the determination to keep trying for a better outcome ("she's a borderline" has historically been a reason not to admit people to hospital, or discharge them more quickly than others, for example). Finally, missing bipolarity because of a diagnosis of "borderline" may lead to an emphasis on using antidepressant medications, which are not thought to make borderline worse; indeed, they can help quite a bit -- but they can definitely make bipolar disorder worse, as you've seen or will see discussed repeatedly elsewhere on this website.
Bottom line: one cannot simply assume that everything which looks like borderline personality disorder "really" is bipolar disorder. In particular, one must be careful not to raise hopes of possible symptom-free life if there is some diagnostic uncertainty about bipolarity versus borderline-ness. At the same time, lowering expectations and treatment effort because a person appears to have borderline traits is a similar pitfall on the opposite side of a presumed best "middle ground" approach.
As you can see, overall my recommendation is that you avoid getting too stuck on a diagnostic label. Which one you get depends a great deal on the orientation of the therapist or doctor! Psychiatrists might be better diagnosticians, in theory, because the they have pliers as well as hammers ("when all you have is a hammer, everything looks like a nail"). But finding a psychiatrist who really does use her/his pliers just as much as his/her hammer can be difficult. Finding a psychiatrist at all can be difficult. In that case, a therapist who feels comfortable treating borderline personality disorder is a good starting place; you can use websites like this one to learn more about the two diagnoses and help guide your treatment from there.
Finally, if you're wondering about what causes borderline personality disorder in the first place, here's a brief essay introducing some new research in that area, about how attachment to parents, particularly moms, is mediated by particular brain chemicals.